منابع مشابه
Homocysteine, stroke, and dementia.
The increase in aging population worldwide is expected to cause an elevation in the prevalence of vascular diseases, including atherosclerosis, hypertension, diabetes mellitus, and hyperlipidemia, as well as their consequences: ischemic heart disease, peripheral vascular disease, and stroke. This will unavoidably result in an increase in the frequency of vascular dementia, which will only be en...
متن کاملFolate Deficiency, Homocysteine and Dementia
Introduction Folate deficiency is relatively common in older adults, and may result from nutritional deficits, malabsorption, medication effects or other causes. Interest in folate and B vitamins has increased in recent years due to their role in homocysteine metabolism. Elevated levels of homocysteine have been implicated in cardiovascular disease,1 and there also have been several recent obse...
متن کاملHomocysteine and stroke.
During the past year epidemiological studies have linked elevated plasma total homocysteine concentrations with an increased risk of ischaemic stroke because of arterial disease. Laboratory studies have further explored the mitogenic effects of total homocysteine on vascular smooth muscle, and cytotoxic and thrombophilic effects on vascular endothelium. Also, a clinical trial has shown that low...
متن کاملHomocysteine and the risk of dementia.
Featured Article: Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D’Agostino RB, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N Engl J Med 2002;346:476 – 83. In the late 1990s, I was working in a tertiary-care academic medical center in India and running a dementia clinic that had enrolled 120 patients in its first year. India is a country where ce...
متن کاملHomocysteine and Dementia: An International Consensus Statement
Identification of modifiable risk factors provides a crucial approach to the prevention of dementia. Nutritional or nutrient-dependent risk factors are especially important because dietary modifications or use of dietary supplements may lower the risk factor level. One such risk factor is a raised concentration of the biomarker plasma total homocysteine, which reflects the functional status of ...
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ژورنال
عنوان ژورنال: Stroke
سال: 2002
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000032551.95449.2a